Silica Exposure and Its Therapeutic Measures against Toxicity

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Silica is one of the most documented workplace contaminants. Multiple serious diseases and increased mortality have been associated with exposure to silica, making it a high priority public health concern in developing and developed nations. Silica intoxication particularly pulmonarytoxicity, genotoxicity and carcinogenicity is widely known. We have designed a non invasive method to determine the respiratory variables of unanesthetized rodents. Despite many years of research we are still far away from effective treatment against toxicity caused due to silica exposure. This review attempts a comprehensive account of recent developments in the research on silica toxicity particularly the role of oxidative stress/ free radicals in the toxic manifestations. The present study was to examine a dietary strategic prevention plan against silica toxicity. We examined Jaggery as a dietary supplement of antioxidants. Jaggery is a natural sweetener made from sugarcane juice (S. officinarum) without the use of any chemicals additives or preservatives. Jaggery contains an enormous wealth of protein, carbohydrate, vitamins and minerals & has been found to have great nutritive and medicinal value.

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